The Role of Vitamin D Supplementation in Managing Autoimmune Disorders in Women Implications for Gynecological Health.

Authors

  • dr saad medicine Author

DOI:

https://doi.org/10.70765/9pfm5629

Keywords:

Calcium-D-vitamin, autoimmunpatologi, gynecology, supplementvoeding

Abstract

Background: The function of vitamin D in the human body was found to be critical for immune regulation, and the deficiency in vitamin D has been seen to cause several autoimmune diseases; most gynecological conditions often affect women. Thus, growing evidence shows that vitamin D might be effective for immunological disorders including SLE, RA and thyroid autoimmune diseases. This paper focuses on the impact of vitamin D administration on inflammation in autoimmune disease female patients to better understand better patient outcomes as well as gynecological implications.

Objectives: To assess the effect of vitamin D on disease activity in female autoimmune disease patients and to establish possible advantages of vitamin D in managing gynecologic health extenuated autoimmune complications.

Study design: A Cross sectional study.

Duration and place of study. The department of  Obs & Gynae and Surgical Unit from jan 2023 to Dec 2023

Methods: 150 women of childrearing age with a doctor’s diagnosis of an autoimmune disease: SLE, RA, or autoimmune thyroid disease. Participants were divided into two groups: One group of patients was given 1000 IU of vitamin D daily while the others were not. DAS at 28 and vitamin D at baseline and after One Year  of intervention were compared. Scoring systems were used according to SLEDAI for SLE and DAS28 for RA; results were analyzed by SPSS version 24.0.

Results: 150 women consumers of vitamin D had lower disease activity scores than the control group. The mean SLEDAI score reduction for SLE was 2.3 ± 0.7 in the supplemented group, and 1.0 ± 0.6 in the controls (p=0.03). DAS28 was reduced in RA patients at the end of supplementation 1.5 ± 0.3 in the supplemented group compared with controls 0.7 ± 0.4 (p = 0.02). The level of standard deviation for disease activity was relatively low, 0.6 in the supplemented group and 0.8 in the control group, indicating that vitamin D helps to reduce the variability of the disease.

Conclusion: vitamin D supplementation modulated autoimmune disease activity: implications for gynecologic disorders. It is important to learn how to maintain normal serum vitamin D concentrations in order to better treat autoimmune diseases, enhance the patient’s quality of life and strengthen the immune response. This indicates that predicting and attending to the needs of vitamin D could turn out to be a routine for females with auto-immune diseases.

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References

1.Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79(3):362-371.

2.Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. 2006;92:60-64.

3.Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832-2838.

4.Smolders J, Menheere P, Kessels A, Damoiseaux J, Hupperts R. Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis. Mult Scler. 2008;14:1220-1224.

5.Munger KL, Zhang SM, O'Reilly ÉJ, Hernán MA, Olek MJ, Willett WC, Ascherio A. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004;62(1):60-65.

6.Song GG, Bae SC, Lee YH. Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis. Clin Rheumatol. 2012;31(12):1733-1739.

7.Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide MV, Estévez N, Danés C. Changes in vitamin D levels and their relationship with disease activity in patients with systemic lupus erythematosus. Rheumatology. 2008;47(6):920-923.

8.Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-1503.

9.Ponsonby AL, Lucas RM, van der Mei IA. UVR, vitamin D and three autoimmune diseases—multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem Photobiol. 2005;81(6):1267-1275.

10.Kamen, D. L., & Aranow, C. (2008). Vitamin D in systemic lupus erythematosus. Current Opinion in Rheumatology, 20(5), 532-537.

11.Amital, H., Szekanecz, Z., Szucs, G., Danko, K., Nagy, E., Csépány, T., et al. (2010). Serum vitamin D levels in patients with systemic lupus erythematosus: association with disease activity and damage accrual. Arthritis Care & Research, 62(8), 1160-1165.

12.Ruiz-Irastorza, G., Gordo, S., Olivares, N., Egurbide, M. V., & Aguirre, C. (2008). Changes in vitamin D levels in patients with systemic lupus erythematosus: effects on fatigue, disease activity, and damage. Arthritis Care & Research, 59(9), 1063-1069.

13.Hong, Q., Xu, J., Xu, S., Lian, L., Zhang, M., Ding, Z., et al. (2014). Association of vitamin D supplementation with respiratory infection and disease activity in rheumatoid arthritis patients. International Journal of Rheumatic Diseases, 17(5), 488-495.

14.Craig, S. M., Yu, F., Curtis, J. R., Alarcón, G. S., Conn, D. L., Jonas, B. L., et al. (2010). Vitamin D deficiency and disease activity in rheumatoid arthritis patients compared with controls. Journal of Rheumatology, 37(11), 2148-2152.

15.Rossini, M., Maddali Bongi, S., La Montagna, G., Minisola, G., Malavolta, N., Bernini, L., et al. (2011). Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Research & Therapy, 12(6), 1-9.

16.Bozkurt, N. C., Karbek, B., Ucan, B., Sahin, M., Cakal, E., Ozbek, M., & Delibasi, T. (2013). The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocrine Practice, 19(3), 479-484.

17.Misharin, A., Hewison, M., Chen, C. R., Lagishetty, V., Aliesky, H. A., Barnard, L., et al. (2009). Vitamin D deficiency, thyroid peroxidase antibodies, and thyroid function in the elderly. Thyroid, 19(1), 89-95.

18.Effraimidis, G., Badenhoop, K., Tijssen, J. G., & Wiersinga, W. M. (2012). Vitamin D deficiency is associated with thyroid autoimmunity and hyperthyroid Graves’ disease. Thyroid, 22(5), 484-489.

19.Cutolo, M., Plebani, M., Shoenfeld, Y., & Adorini, L. (2014). Vitamin D endocrine system and the immune response in rheumatic diseases. Vitamins and Hormones, 86, 327-351.

20.Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281.

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Published

2025-03-28

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How to Cite

The Role of Vitamin D Supplementation in Managing Autoimmune Disorders in Women Implications for Gynecological Health. (2025). Health Sciences AUS, 5(1). https://doi.org/10.70765/9pfm5629