The Role of Vitamin D Supplementation in orthopedic trauma patients
DOI:
https://doi.org/10.70765/bfzkax62Keywords:
Vitamin D supplementation, trauma patients, disease activity, orthopedic rehabilitationAbstract
This randomized controlled trial evaluated the effects of vitamin D supplementation on disease activity in trauma patients with baseline vitamin D deficiency at Hayatabad Medical Complex's Orthopedic Ward from July 2024 to March 2025. A total of 150 patients with bike trauma, firearm trauma, or history of falls were equally divided into supplemented (n=75) and control (n=75) groups. The supplemented group received 50,000 IU vitamin D3 weekly for 8 weeks followed by 2000 IU/day maintenance, while controls received standard care. Results demonstrated significantly greater reductions in disease activity scores in supplemented patients across all trauma types: bike trauma (2.4 vs 1.0, p=0.04), firearm trauma (1.6 vs 0.7, p=0.03), and history of falls (1.1 vs 0.5, p=0.05). The supplemented group also showed more stable outcomes (SD=0.7) compared to controls (SD=0.9) and achieved substantial increases in vitamin D levels (14 to 46 ng/mL) versus minimal change in controls (16 to 17 ng/mL). These findings indicate that vitamin D supplementation significantly improves disease activity and reduces clinical variability in trauma patients, supporting its potential role in orthopedic rehabilitation protocols for vitamin D-deficient individuals.
Downloads
References
1: Agoncillo M, Yu J, Gunton JE. The role of vitamin D in skeletal muscle repair and regeneration in animal models and humans: a systematic review. Nutrients. 2023; 15(20): 4377.
2: Albright JA, Chang K, Byrne RA, Quinn MS, Meghani O, Daniels AH, et al. A diagnosis of vitamin D deficiency is associated with increased rates of anterior cruciate ligament tears and reconstruction failure. Arthroscopy. 2023; 39(12): 2477–2486.
3: Aujla RS, Allen PE, Ribbans WJ. Vitamin D levels in 577 consecutive elective foot & ankle surgery patients. Foot Ankle Surg. 2019; 25(3): 310–315.
4: Barker T, Henriksen V, Martins T, Hill H, Kjeldsberg C, Schneider E, et al. Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 2013; 5(4): 1253–1275.
5: Boyan BD, Hyzy SL, Pan Q, Scott KM, Coutts RD, Healey R, et al. 24R,25-Dihydroxyvitamin D3 protects against articular cartilage damage following anterior cruciate ligament transection in male rats. Plos One. 2016; 11(8):e0161782.
6: Song GG, Bae SC, Lee YH. Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis. Clin Rheumatol. 2012;31(12):1733-1739.
7: Amital, H., Szekanecz, Z., Szucs, G., Danko, K., Nagy, E., Csépány, T., et al. (2010). Serum vitamin D levels in patients with systemic lupus erythematosus: association with disease activity and damage accrual. Arthritis Care & Research, 62(8), 1160-1165.
8: Hong, Q., Xu, J., Xu, S., Lian, L., Zhang, M., Ding, Z., et al. (2014). Association of vitamin D supplementation with respiratory infection and disease activity in rheumatoid arthritis patients. International Journal of Rheumatic Diseases, 17(5), 488-495.
9: Craig, S. M., Yu, F., Curtis, J. R., Alarcón, G. S., Conn, D. L., Jonas, B. L., et al. (2010). Vitamin D deficiency and disease activity in rheumatoid arthritis patients compared with controls. Journal of Rheumatology, 37(11), 2148-2152.
10: Rossini, M., Maddali Bongi, S., La Montagna, G., Minisola, G., Malavolta, N., Bernini, L., et al. (2011). Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Research & Therapy, 12(6), 1-9.
11: Bozkurt, N. C., Karbek, B., Ucan, B., Sahin, M., Cakal, E., Ozbek, M., & Delibasi, T. (2013). The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocrine Practice, 19(3), 479-484.
12: Effraimidis, G., Badenhoop, K., Tijssen, J. G., & Wiersinga, W. M. (2012). Vitamin D deficiency is associated with thyroid autoimmunity and hyperthyroid Graves’ disease. Thyroid, 22(5), 484-489.
13: Cutolo, M., Plebani, M., Shoenfeld, Y., & Adorini, L. (2014). Vitamin D endocrine system and the immune response in rheumatic diseases. Vitamins and Hormones, 86, 327-351.
14: Campbell M, Katikireddi SV, Sowden A, McKenzie JE, Thomson H. Improving Conduct and Reporting of Narrative Synthesis of Quantitative Data (ICONS-Quant): protocol for a mixed methods study to develop a reporting guideline. BMJ Open. 2018; 8(2):e020064.
15:Chiang C, Ismaeel A, Griffis RB, Weems S. Effects of vitamin D supplementation on muscle strength in athletes: a systematic review. J Strength Cond Res. 2017; 31(2): 566–574
Downloads
Published
Issue
Section
License
Copyright (c) 2025 dr inzimam chughtai (Author); Dr Muhammad Abbas (Translator)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes .
- NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.